How can we improve access to new (and old) antibiotics in Australia?

Allen C Cheng and Roger L Nation
Med J Aust 2013; 199 (2): . || doi: 10.5694/mja13.10657
Published online: 22 July 2013

It is hoped that new registration mechanisms and economic incentives will encourage much-needed drug development

That there is a problem with antibiotic resistance is no surprise to clinicians who deal with antibiotic-resistant organisms in day-to-day practice. Scenarios increasingly being faced include health care-associated infections (particularly those acquired overseas) where few therapeutic options are available, bacteraemia following transrectal prostate biopsy, simple urinary tract infections for which no oral antibiotics are effective, and drug-resistant gonorrhoea, tuberculosis and typhoid fever. The inexorable rise in antibiotic resistance coincides with a dwindling pipeline of novel antimicrobial agents under development.1,2 A recent review identified only two new antibiotics registered in the United States since 2009 (of which only one is currently available in Australia) and only seven antibiotics active against gram-negative bacteria in clinical development.3 Only four multinational pharmaceutical companies were engaged in the development of antibacterials; barriers to development and registration of new antibiotics were noted (including the need for large efficacy and safety trials), as was low profitability relative to other drugs.

  • Allen C Cheng1,2
  • Roger L Nation3

  • 1 Infectious Disease Epidemiology Unit, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC.
  • 2 Infection Prevention and Healthcare Epidemiology Unit, Alfred Health, Melbourne, VIC.
  • 3 Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC.


Competing interests:

Allen Cheng is a member of the TGA’ s Advisory Committee on Prescription Medicines. The views outlined here do not necessarily reflect the views of the Committee or the TGA.


remove_circle_outline Delete Author
add_circle_outline Add Author

Do you have any competing interests to declare? *

I/we agree to assign copyright to the Medical Journal of Australia and agree to the Conditions of publication *
I/we agree to the Terms of use of the Medical Journal of Australia *
Email me when people comment on this article

Online responses are no longer available. Please refer to our instructions for authors page for more information.