Lessons from the bedside: ketoacidosis and SGLT2 inhibitors

Yvonne Y Chow, Roisin Worsley and Duncan J Topliss
Med J Aust 2016; 205 (4): . || doi: 10.5694/mja16.00435
Published online: 15 August 2016

Sodium–glucose cotransporter type 2 (SGLT2) inhibitors are an emerging oral glucose-lowering therapy. In May 2015, the United States Food and Drug Administration issued a warning amid observation of ketoacidosis cases that may have been associated with SGLT2 inhibitor use in people with type 2 diabetes (T2DM). Potential mechanisms include inhibition of insulin secretion through glycosuria, increased glucagon secretion and hypovolaemia.1-3

  • Yvonne Y Chow
  • Roisin Worsley
  • Duncan J Topliss

  • Alfred Hospital, Melbourne, VIC



We thank our two patients for kindly allowing us to describe their cases.

Competing interests:

No relevant disclosures.


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